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Symbol | Exchange | Currency | ||
---|---|---|---|---|
VSTM | NASDAQ | USD | Real-time | |
0LOV | London | USD | Real-time | |
2VSA | TradeGate | EUR | Delayed | |
2VSA | Frankfurt | EUR | Delayed |
Verastem, Inc., a development-stage biopharmaceutical company, focuses on developing and commercializing drugs for the treatment of cancer in the United States. Its product candidates are Avutometinib, an orally available small molecule RAF/MEK clamp that inhibits the ras sarcoma RAF/MEK, ERK mitogen activated pathway kinase pathway which is involved in cell proliferation, migration, transformation, and survival of tumor cells; and Defactinib, an oral small molecule inhibitor of FAK and proline-rich tyrosine kinase for various solid tumors. The company is involved in clinical studies, including RAMP 301, a randomized global confirmatory trial to evaluate the combination of Avutometinib and Defactinib for the treatment of patients with recurrent low-grade serous ovarian cancer; RAMP 201, an adaptive two-part multicenter, parallel cohort, randomized open label trial to evaluate the efficacy and safety of Avutometinib and in combination with Defactinib; and FRAME, an investigation of Avutometinib and Defactinib in patients with KRAS mutant cancers and subsequent analyses; and RAMP 204 and 205. It has license agreements with Chugai Pharmaceutical Co., Ltd. for the development, commercialization, and manufacture of products containing Avutometinib; and Pfizer Inc. to research, develop, manufacture, and commercialize products containing Pfizer’s inhibitors of FAK for therapeutic, diagnostic, and prophylactic uses in humans. In addition, it has a clinical collaboration agreement with Amgen, Inc. to evaluate the combination of Avutometinib with Amgen’s KRAS-G12C inhibitor LUMAKRAS which in Phase 1/2 trial entitled RAMP 203; and a discovery and development collaboration with GenFleet Therapeutics to advance new programs targeting RAS pathway-driven cancers. Verastem, Inc. was incorporated in 2010 and is headquartered in Needham, Massachusetts.
Name | Age | Since | Title |
---|---|---|---|
Robert E. Gagnon | 49 | 2018 | Director |
Mario Sznol | 65 | - | Member of Scientific Advisory Board |
Paul A. Bunn | 78 | 2021 | Independent Director |
Michael Glen Kauffman | 60 | 2012 | Lead Independent Director |
Robert A. Weinberg | - | - | Co-Founder & Chair of Scientific Advisory Board |
Brian M. Stuglik | 64 | 2017 | Director |
Daniel W. Paterson | 62 | 2012 | President, CEO & Director |
Eric K. Rowinsky | 66 | 2017 | Independent Director |
John H. Johnson | 65 | 2020 | Independent Director |
Michelle Robertson | 56 | 2021 | Independent Director |
Channing J. Der | - | 2022 | Member of Scientific Advisory Board |
Anil Kapur | 53 | 2022 | Independent Director |
Karin Tollefson | 57 | 2023 | Independent Director |
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