Novogen: Anisina Nixed, GDC-0084 On Track For Phase Ii
Edison | May 22, 2017 07:18AM ET
Novogen Limited's (NASDAQ:NVGN) recent market updates presented mixed news for investors. Recruitment in the Cantrixil Phase I is underway and preparations for the Phase II trial of GDC-0084 in glioblastoma are progressing well, although headline data are now likely in H1 CY20, 12 months later than we initially forecast. Mixed data from preclinical studies have seen development terminated for Anisina, which had been expected to enter the clinic in H217. While the termination of Anisina is disappointing, it is encouraging to see that management is taking a disciplined approach to assessing pipeline products. We now value Novogen between A$86m (A$0.18/share) and A$146m (A$0.30/share) under two different development scenarios for GDC-0084. Major milestones anticipated in 2017 include initiation of a Phase II trial of GDC-0084 and full enrolment in the Cantrixil Phase I.
Cantrixil enters the clinic
The Phase I trial of Cantrixil in patients with recurrent or refractory ovarian cancer is expected to enrol up to 60 patients in the US and Australia and to be fully enrolled by Q417. While the primary aim is to assess dosage, safety and tolerability, radiological responses and biomarkers will be assessed for indications of efficacy.
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