Zacks Investment Research | Dec 04, 2019 09:24PM ET
Myriad Genetics, Inc. (NASDAQ:MYGN) publishes favorable study results on the Prequel Prenatal Screen in the journal Prenatal Diagnosis. The highlight of the study is to prove the superiority of Prequel over the traditional non-DNA screening used for identifying chromosomal abnormalities in pregnant women, including those with high body mass index (BMI).
Per the company, almost half the population of pregnant women have a BMI that can adversely affect the accuracy of the non-invasive prenatal screening (NIPS). This, in turn, leads to patient anxiety, and more expensive and invasive screening methods like amniocentesis or chorionic villus sampling.
With the positive outcome of NIPS, Myriad Genetics aims to strengthen foothold in the global NIPS test market — a segment of the company’s molecular diagnostic testing business.
About the Study
Prequel’s performance is based on the whole genome sequencing (WGS) approach, which identifies chromosomal irregularities like trisomy 21 (T21), trisomy 18 (T18) and trisomy 13 (T13). The Prequel screen uses cell-free DNA (cfDNA) to decide whether the pregnancy is at an increased risk for chromosome abnormalities, such as Down syndrome.
The Prequel Prenatal Screen: A Breakthrough
According to the previous results of the study, Prequel is accurate at all FF levels and does not necessitate a FF cutoff like other NIPS offerings. However, in the current study, the company has demonstrated the efficacy of Prequel in all women, irrespective of their BMI, race or ethnicity. This is an upgrade from the traditional NIPS, which had a higher fetal fraction (FF) cutoff and non-DNA screening methods.
It also indicated that the tests that are required to use a FF cutoff may actually underperform at higher BMIs, unlike the Prequel. This, in turn, will ease patient’s anxiety to some extent after the first screening itself, accelerating diagnosis.
Industry Prospects
Per a report by Zacks Investment Research
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