Merck's Keytruda Misses One Of Two Goals In Lung Cancer Study
Zacks Investment Research | Jan 06, 2020 10:02PM ET
Merck & Co., Inc.’s (NYSE:MRK) late-stage study, evaluating its blockbuster PD-L1 inhibitor Keytruda as first-line treatment for extensive stage small cell lung cancer (SCLC), failed to meet one of the two primary endpoints.
While the phase III KEYNOTE-604 study evaluating Keytruda plus chemotherapy for the above indication met one of its dual primary endpoints of progression-free survival (PFS), it failed to meet the other endpoint of overall survival (OS). The data showed that treatment with Keytruda plus chemotherapy (etoposide plus cisplatin or carboplatin) led to a statistically significant improvement in PFS compared to chemotherapy alone. However, while the combination showed an improvement in OS, the OS results did not meet statistical significance
Merck’s shares were down more than 1% in after-hours trading in response. Merck’s shares have risen 21.5% in the past year compared with the Zacks Investment Research
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