Zacks Investment Research | Nov 19, 2019 08:41PM ET
Shares of The Medicines Company (NASDAQ:MDCO) surged almost 20% on Nov 19 following a Bloomberg industry ’s growth of 2.5%.
Data from the studies showed that 18 months of treatment with inclisiran led to a reduction in LDL-C level of more than 50% in patients with heterozygous familial hypercholesterolemia (HeFH) and atherosclerotic cardiovascular disease (ASCVD). The patients were treated with the maximum tolerated dose of statin therapy alone or in combination with Merck’s (NYSE:MRK) Zetia. Moreover, inclisiran will also allow much less frequent dosing in patients compared to other popular LDL-C lowering drugs like Sanofi/Regeneron’s Praluent and Amgen’s Repatha. While Praluent and Repatha are approved with once every two weeks or once a month dosing, inclisiran has been developed for twice-a-year dosing.
With several drugs of Novartis set to lose patent protection over the next few years, the company is focused on strengthening its pipeline with the inclusion of next-generation treatments for several diseases. The inclusion of inclisiran in Novartis’ commercial portfolio is likely to boost its cardiovascular portfolio further.We expect that the acquisition of inclisiran by Novartis will boost the candidate’s prospects as the company has a strong position in the market and cash resources to support the launch and fight competition.
However, Novartis and The Medicines Company have not confirmed the deal. Moreover, it is rumored that there can be bidders for The Medicines Company other than Novartis.
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