Inside Biotech Agenus

 | Apr 29, 2013 11:56AM ET

Today, we look into at a company that has an imminent catalyst, a number of important Phase II and Phase III data releases throughout 2013 and a product pipeline with potential to tap into a $17B market.

AgenusTHLD ) also has a similar therapy for patients with reoccurring Glioblastoma termed TH-302. TH-302 is a Tumor Hypoxia-Targeted Drug, which is also combined with AVASTIN (Bevacizumab) in a Phase I/II trial to treat brain cancer patients. Threshold is in the early stage with this study, but is anticipating positive data from TH-302 for this very devastating and malignant disease.

Glioblastoma is an indication in which safe and effective therapies are very much needed.

Other Catalysts This Year
Agenus has already reported positive Phase III results in late 2012 for the QS-21 Stimulon Adjuvant in GlaxoSmithKline's RTS,S for Malaria and has several other trials underway for additional indications. These catalysts include Phase III Mage A3 for Melanoma, and Phase III A3 for non-small cell lung cancer. Agenus is also partnered with GalaxoSmithKline for both of these indications. Furthermore, a Phase II HerpV trial for Genital Herpes is underway, with data due in the fourth quarter of 2013.

Speculating further into the future, Agenus has a Phase III trial for HZ/su for shingles with data due in 2014 and also 10 other undisclosed indications.

Financial Position
According to Agenus' latest financial report, the company recently retired its outstanding $39 million 8.00% senior secured convertible notes due August 2014. These Notes were exchanged for $10 million in cash, 2,500,000 shares of common stock and a twenty percent revenue interest from QS-21 Stimulon partnered programs. In addition, the company entered into two separate $5 million debt transactions for $10 million total in notes plus 500,000 share warrants. Following these transactions, Agenus' total debt obligation outstanding is $10 million, down from $39 million.