Immutep: LAG-3 Progress In-House And Via Partners
Edison | Aug 30, 2018 08:56AM ET
Immutep Ltd (AX:IMM) has reported encouraging progress from its in-house and partnered programmes over the past few months. Interim data from the TACTI-mel combo study included a 61% response rate from the start of the Keytruda monotherapy screening period among subjects who went on to receive eftilagimod alpha (efti or IMP321) combo therapy. Partners GSK and Novartis are progressing their in-licensed LAG-3 programmes into Phase II or proof of concept studies, which increases the likelihood that these programmes will return significant value to Immutep. Our valuation has increased to A$510m or A$0.17/share (from A$439m or A$0.14/share).
Encouraging TACTI-mel data – update due November
Patients in the first three TACTI-mel cohorts showed a 33% response rate from the start of efti/Keytruda combo therapy and 61% from the start of the Keytruda monotherapy screening period. The six-patient additional cohort is fully recruited; treatment with efti started at the same time as Keytruda (vs 12 weeks after the start of Keytruda therapy in the first three cohorts). A data update is due in November.
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LAG-3 Progress In-House And Via Partners
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