BioLineRx Begins Part 2 Of Phase I/IIa Study On Solid Tumors
Zacks Investment Research | Sep 25, 2019 09:00PM ET
BioLineRx Ltd. (NASDAQ:BLRX) announced the dosing of the first patient in the part 2 of the phase I/IIa study on AGI-134. AGI-134 is a synthetic alpha-Gal glycolipid in development for solid tumors and highly differentiated from other cancer immunotherapies.
The study will evaluate the safety and tolerability of AGI-134 at doses up to the recommended dose in multiple solid tumor types and a wide array of biomarkers, and validate AGI-134's mechanism of action. Further, efficacy will be assessed by clinical and pharmacodynamic parameters. The company expects initial results from the part 2 of the study by 2020 end.
The company initiated the part 2 of the studyafter the successful completion of the part 1 and the determination of the recommended dose. In preclinical studies, AGI-134 led to regression of established primary tumors and prevented the growth of secondary tumors. The candidate also triggered a vaccine effect that may prevent the development of future metastases.
Shares of the company have plunged 59.2% year to date against the Zacks Investment Research
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