Bayer's Generic Competition, Pipeline Setback Issues Remain

 | May 29, 2018 05:45AM ET

We issued an updated research report on Bayer AG (DE:BAYGN) (OTC:BAYRY) on May 28.

Bayer is facing generic threats/competition for many of its products including the Yaz franchise (oral contraceptives). The genericization of key drugs would negatively impact revenues. We expect the declining Yaz sales trend to persist. Continued weak performance of key drugs could impact the company’s top line and pull down the stock.

Bayer has a number of candidates in its pipeline and any adverse pipeline-related news has the potential to impact the stock adversely. In May 2016, Bayer announced the termination of a phase II study on Adempas in patients with pulmonary hypertension associated with idiopathic interstitial pneumonias. The decision followed the recommendation of an independent Data Monitoring Committee, which observed that patients dosed with Adempas were at a greater risk of death and other serious adverse events than those on the placebo arm.

In June 2017, Bayer announced that a phase II study evaluating its investigational oncology compound anetumab ravtansine (BAY 949343) as a monotherapy in patients with recurrent malignant pleural mesothelioma (MPM), who were previously treated, did not meet its primary endpoint of progression-free survival.

Bayer’s dependence on its pharmaceutical segment for growth remains a concern.

Year to date, shares of the company have declined 5.1%, compared with the industry ’s decline of 4.8%.