AstraZeneca (AZN) Up on Enhertu, Imfinzi Cancer Data at ESMO (Revised)
Zacks Investment Research | Sep 30, 2021 01:21AM ET
AstraZeneca (NASDAQ:AZN)’s industry .
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AstraZeneca had acquired joint development and commercialization rights to Enhertu from Japan’s Daiichi Sankyo in April 2019. Sales of Enhertu in the United States are recognized by Daiichi Sankyo while AstraZeneca records its share of profit from the sales of the drug in the United States as collaboration revenues. Enhertu was approved for its second indication, HER2+, metastatic gastric cancer in January 2021 while it is also being evaluated for other cancer types.
At ESMO, AstraZeneca also presented three-year data from the CASPIAN phase III study in its PD-L1 inhibitor, Imfinzi. The data showed that Imfinzi plus chemotherapy tripled patient survival at three years in first-line extensive-stage small cell lung cancer
Please note that Imfinzi is already approved for the first-line treatment of extensive-stage small cell lung cancer in combination with standard-of-care platinum chemotherapy in several countries based on OS data from the CASPIAN phase III study. The latest results from the CAPIAN study showed that Imfinzi plus chemotherapy resulted in a 29% reduction in the risk of death versus chemotherapy alone after a median follow up of more than three years. The data also showed that an estimated 17.6% of patients in the Imfinzi plus chemotherapy arm were alive at three years, versus 5.8% of those in the chemotherapy alone arm. Median OS was 12.9 months in the Imfinzi plus chemotherapy arm against 10.5 for the chemotherapy alone arm.
Imfinzi is also approved to treat unresectable, stage III non-small-cell lung cancer (NSCLC).
Enhertu and Imfinzi are part of AstraZeneca’s flourishing oncology portfolio. Other key oncology drugs in AstraZeneca’s portfolio are Tagrisso and Lynparza. AstraZeneca markets Lynparza in partnership with MerckREGN , which has a Zacks Rank #1 (Strong Buy).
Regeneron’s shares have gained 32.7% this year so far. Its earnings estimates for 2021 and 2022 have risen from $50.00 per share to $58.89.
(We are reissuing this article to correct a mistake. The original article, issued on September 21, 2021, should no longer be relied upon.)
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