ASLAN's Varlitinib Fails To Meet Endpoint In Phase II Study
Zacks Investment Research | Jan 13, 2019 09:46PM ET
ASLAN Pharmaceuticals Limited (NASDAQ:ASLN) announced that a phase II study, evaluating its pipeline candidate — varlitinib — for the treatment of first-line gastric cancer, failed to meet the primary endpoint of showing significant reductions in tumor size. The study was examining varlitinib plus mFOLFOX6 compared with placebo plus mFOLFOX6 as a first-line therapy for the treatment of HER1/HER2 co-expressing advanced or metastatic gastric cancer.
Data from the study, obtained from an independent central review, proved that patients having received varlitinib + mFOLFOX6 showed an average tumor reduction of 22% compared with the 12.5% decrease for those administered with mFOLFOX6 alone following a 12-week treatment regime. However, this difference did not reach statistical significance.
Notably, the combo of Varlitinib and mFOLFOX6 was well-tolerated in the program. The company also stated that a trend toward an improvement in progression free survival was observed in the study.
Shares of ASLAN have plummeted 51.3% in the past six months, wider than the Zacks Investment Research
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